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About

MHI Cardiovascular Physiology and Phenotyping Core (CPPC)

Mission:

The MHI Cardiovascular Physiology and Phenotyping Core (CPPC) provides surgical, imaging and functional assessment services with a focus on cardiovascular system in rodents. 

Services (Please contact the Core before the first order): 

1. Animal models and microsurgery*

  • Myocardial Infarction (LCA permanent ligation, verified by ECG measurement)**
  • Ischemia-Reperfusion (LCA temporary ligation, verified by ECG measurement)**
  • Pressure Overload (Aortic constriction, verified by PW Doppler ultrasound)**
  • Minipump/Telemetry Implantation in mice and rats
  • Arterial and venous cannulation
  • Carotid or renal artery ligation
  • ferric chloride-induced thrombosis model
  • Cardiac arrest/resuscitation murine model
  • Customized surgeries 

* Mice are discounted the full price if
    a. They do not make it off the surgical table or
    b. Technical failure: the blood flow velocity in TAC mice or ECG signal in MI mice does not match the requirement.
** The PW Doppler measurement and ECG measurement are included in services. Data are available upon reques.

2. Echocardiographic and electrocardiographic studies

  • B/M mode (parasternal long or short axis view of the left ventricle) in conscious mice
  • Color Doppler and Pulsed Wave Doppler (Apical four chamber view or blood flow velocity)
  • ECG measurement

3. Isolation of adult and neonatal cardiomyocytes

  • Langendorff-perfusion based isolation of adult cardiomyocytes

4. Functional assessments of cardiovascular phenotypes

  • PV loops
  • Langendorff and working heart system
  • Invasive blood pressure measurement

5. Equipment rent

  • Vevo2100 Ultrasound system (Echocardiography)
  • CODA® High Throughput System (Non-invasive blood pressure measurement)
  • Surgical table with Zeiss two-head surgical Microscope
  • Ultra Precise Small Animal Stereotaxic instrument
  • Workstation with LabChart 8.0 pro and Vevo Lab

Leadership

Jonathan C. Schisler Faculty Director
Charlene M. Santos Core Director
Aung Moe Zaw Core Manager
Delphine Bull Christman Billing Manager
   
   

Location and hours of operation

Hours Location

Monday - Friday 

9AM - 5PM

111 Mason farm Road

3306 MBRB

Chapel Hill, NC 27599

Links and Resources

https://www.med.unc.edu/mhi/surgicalmodels/

Contacts

Name Role Phone Email Location
Aung Moe Zaw
Core Manager
 
(919) 966-3036
 
aung-moe_zaw@med.unc.edu
 
3006A MBRB
 
Charlene M. Santos
Core Director
 
(919) 843-7988
 
csantos@unc.edu
 

 
Jonathan C. Schisler
Faculty Director
 
(919) 843-8708
 
schisler@unc.edu
 
3340C MBRB
 
Delphine Bull Christman
Business Officer
 
(919) 962-4559
 
delphine_bull@med.unc.edu
 
3356 Genome Science Bldg
 

Service list


Search available services: View: by category alphabetically
► Assessment of cardiac function (4)
► Isolation of Cardiomyocytes (1)
► Microsurgery - Mouse (6)
► Microsurgery - Rat (1)