NORC Animal Metabolism Phenotyping Core

Mouse breeding, colony management, sample handling, restrain and care, and other laboratory
techniques/services as defined by the animal protocol set forth by the project. These services will be
performed by trained core staff using approved techniques.

Mouse breeding, colony management, sample handling, restrain and care, and other laboratory techniques/services as defined by the animal protocol set forth by the project. These services will be performed by trained core staff using approved techniques.

The calorimetry instrumentation (TSE systems) is used to evaluate and interpret energy expenditure in mice. The system measures O2 consumption & CO2 production, respiratory exchange rate, and energy expenditure in the home cage environment. The indirect calorimetry can also evaluate and interpret energy expenditure in 3-D (X, Y and Z dimension) via light beams for up to 10-days using intervals between 1 to 60 minutes in the home cage environment.
Priced Per Mouse/day
Minimum of 2 days

The calorimetry instrumentation (TSE systems) is used to evaluate and interpret energy expenditure in mice. The system measures O2 consumption & CO2 production, respiratory exchange rate, and energy expenditure in the home cage environment. Using a voluntary running wheel within the same cage, wheel activity is measured by daily summary measurements including total daily revolutions, time spent running (i.e., cumulative 1-minute intervals in which at least one revolution was recorded), average speed (total revolutions / time spent running) and maximum speed (highest number of revolutions in any one-minute interval within a 24 hour period) are recorded.

Priced Per Mouse/day
Minimum of 2 days

For behavioral, metabolic, or physiological experiments that require thermo-neutral conditions, the Constant Climate Chamber (Memmert HPP 750) provides full control over temperature, humidity and lighting conditions. The chambers have a temperature range (with light) from 0°C up to +40°C, and they can hold up to 16 cages at a time and up to 5 mice per cage.

 Priced per day, for 0-8 cages

This custom system combines 15 metabolic cages (Hatteras Instruments) and a cooling unit. The cooling unit keeps the urine samples at or below 45F during the collection. Different from traditional non-chilled metabolic cages, this system will prevent bacterial multiplication, improve sample quality and increase the sample shelf life. Useful for studies on the effects of drug therapies, urinary protein excretion, renal function studies, evaluation of standard or intervened metabolic function, and daily food and water intake. Suggested collection period, 6-24 hours.

Priced Per Mouse

This custom system combines 15 metabolic cages (Hatteras Instruments) and a cooling unit. The cooling unit keeps the urine samples at or below 45F during the collection. Different from traditional non-chilled metabolic cages, this system will prevent bacterial multiplication, improve sample quality and increase the sample shelf life. Useful for studies on the effects of drug therapies, urinary protein excretion, renal function studies, evaluation of standard or intervened metabolic function, and daily food and water intake. Suggested collection period, 6-24 hours.
Priced Per Mouse

MRI scanner technology used to evaluate whole body composition (including fat mass, lean mass, and free and total water masses) in live mice without anesthesia.

Priced Per Mouse

Performed with the Seahorse XFe96 analyzer, the XF Cell Energy Phenotype Test takes simultaneous measurements of oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) to provide a metabolic “snapshot” of samples. This service will be performed by trained core staff using approved techniques. Trained core staff will also provide training on the Seahorse XFe96 analyzer, including showing space/incubator, explaining how to save data and log hours, density/optimizations, plate layout, etc.

Learn more about our Seahorse services here.

Performed with the Seahorse XFe96 analyzer, the XF Cell Mito Stress Test measures the key parameters of mitochondrial function. This service will be performed by trained core staff using approved techniques. Trained core staff will also provide training on the Seahorse XFe96 analyzer, including showing space/incubator, explaining how to save data and log hours, density/optimizations, plate layout, etc.

Learn more about our Seahorse services here.

Performed with the Seahorse XFe96, the XF Glycolysis Stress Test measures key parameters of glycolytic function. This service will be performed by trained core staff using approved techniques. Trained core staff will also provide training on the Seahorse XFe96 analyzer, including showing space/incubator, explaining how to save data and log hours, density/optimizations, plate layout, etc.

Learn more about our Seahorse services here.

This service is performed with the Seahorse XFe96 analyzer by trained core staff using approved techniques. Trained core staff will also provide training on the Seahorse XFe96 analyzer, including showing space/incubator, explaining how to save data and log hours, density/optimizations, plate layout, etc.

Learn more about our Seahorse services here.

This service is performed with the Seahorse XFe96 analyzer by trained core staff using approved techniques. Trained core staff will also provide training on the Seahorse XFe96 analyzer, including showing space/incubator, explaining how to save data and log hours, density/optimizations, plate layout, etc.

Learn more about our Seahorse services here.

Expertise provided on study design, data interpretation, quality control, and analysis methods.

Expertise provided on study design, data interpretation, quality control, and analysis methods.

The Exer-3/6 treadmill is a general purpose animal exerciser. This analysis includes 3 adaptations and one-maximal performance measurement. These tests help to examine the metabolic parameters in mice using speed, acceleration, and distance traveled as measures. The data is recorded and analyzed by the core using statistical Exer-3/6 software.

Priced Per Mouse

Using the voluntary running wheel, daily summary measurements including total daily revolutions, time spent running (i.e., cumulative 1-minute intervals in which at least one revolution was recorded), average speed (total revolutions / time spent running) and maximum speed (highest number of revolutions in any one-minute interval within a 24 hour period) are recorded and analyzed in mice.

Priced Per Mouse

Using the voluntary running wheel, daily summary measurements including total daily revolutions, time spent running (i.e., cumulative 1-minute intervals in which at least one revolution was recorded), average speed (total revolutions / time spent running) and maximum speed (highest number of revolutions in any one-minute interval within a 24 hour period) are recorded and analyzed in mice.

Priced Per Mouse

This custom system combines 15 metabolic cages (Hatteras Instruments) and a cooling unit. The cooling unit keeps the urine samples at or below 45F during the collection. Different from traditional non-chilled metabolic cages, this system will prevent bacterial multiplication, improve sample quality and increase the sample shelf life. Useful for studies on the effects of drug therapies, urinary protein excretion, renal function studies, evaluation of standard or intervened metabolic function, and daily food and water intake. Suggested collection period, 6-24 hours.

Priced Per Mouse

The Exer-3/6 treadmill is a general purpose animal exerciser. This analysis includes 3 adaptations and one-maximal performance measurement. These tests help to examine the metabolic parameters in mice using speed, acceleration, and distance traveled as measures. The data is recorded and analyzed by the core using statistical Exer-3/6 software.

Priced Per Mouse

Expertise provided on study design, data interpretation, quality control, and analysis methods.

Mouse breeding, colony management, sample handling, restrain and care, and other laboratory
techniques/services as defined by the animal protocol set forth by the project. These services will be
performed by trained core staff using approved techniques.

Performed with the Seahorse XFe96 analyzer, the XF Cell Mito Stress Test measures the key parameters of mitochondrial function. This service will be performed by trained core staff using approved techniques. Trained core staff will also provide training on the Seahorse XFe96 analyzer, including showing space/incubator, explaining how to save data and log hours, density/optimizations, plate layout, etc.

Learn more about our Seahorse services here.

Performed with the Seahorse XFe96, the XF Glycolysis Stress Test measures key parameters of glycolytic function. This service will be performed by trained core staff using approved techniques. Trained core staff will also provide training on the Seahorse XFe96 analyzer, including showing space/incubator, explaining how to save data and log hours, density/optimizations, plate layout, etc.

Learn more about our Seahorse services here.

This service is performed with the Seahorse XFe96 analyzer by trained core staff using approved techniques. Trained core staff will also provide training on the Seahorse XFe96 analyzer, including showing space/incubator, explaining how to save data and log hours, density/optimizations, plate layout, etc.

Learn more about our Seahorse services here.

Performed with the Seahorse XFe96 analyzer, the XF Cell Energy Phenotype Test takes simultaneous measurements of oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) to provide a metabolic “snapshot” of samples. This service will be performed by trained core staff using approved techniques. Trained core staff will also provide training on the Seahorse XFe96 analyzer, including showing space/incubator, explaining how to save data and log hours, density/optimizations, plate layout, etc.

Learn more about our Seahorse services here.

This service is performed with the Seahorse XFe96 analyzer by trained core staff using approved techniques. Trained core staff will also provide training on the Seahorse XFe96 analyzer, including showing space/incubator, explaining how to save data and log hours, density/optimizations, plate layout, etc.

Learn more about our Seahorse services here.

MRI scanner technology used to evaluate whole body composition (including fat mass, lean mass, and free and total water masses) in live mice without anesthesia.

Priced Per Mouse

The calorimetry instrumentation (TSE systems) is used to evaluate and interpret energy expenditure in mice. The system measures O2 consumption & CO2 production, respiratory exchange rate, and energy expenditure in the home cage environment. The indirect calorimetry can also evaluate and interpret energy expenditure in 3-D (X, Y and Z dimension) via light beams for up to 10-days using intervals between 1 to 60 minutes in the home cage environment.
Priced Per Mouse/day
Minimum of 2 days

The calorimetry instrumentation (TSE systems) is used to evaluate and interpret energy expenditure in mice. The system measures O2 consumption & CO2 production, respiratory exchange rate, and energy expenditure in the home cage environment. Using a voluntary running wheel within the same cage, wheel activity is measured by daily summary measurements including total daily revolutions, time spent running (i.e., cumulative 1-minute intervals in which at least one revolution was recorded), average speed (total revolutions / time spent running) and maximum speed (highest number of revolutions in any one-minute interval within a 24 hour period) are recorded.

Priced Per Mouse/day
Minimum of 2 days

This custom system combines 15 metabolic cages (Hatteras Instruments) and a cooling unit. The cooling unit keeps the urine samples at or below 45F during the collection. Different from traditional non-chilled metabolic cages, this system will prevent bacterial multiplication, improve sample quality and increase the sample shelf life. Useful for studies on the effects of drug therapies, urinary protein excretion, renal function studies, evaluation of standard or intervened metabolic function, and daily food and water intake. Suggested collection period, 6-24 hours.
Priced Per Mouse

For behavioral, metabolic, or physiological experiments that require thermo-neutral conditions, the Constant Climate Chamber (Memmert HPP 750) provides full control over temperature, humidity and lighting conditions. The chambers have a temperature range (with light) from 0°C up to +40°C, and they can hold up to 16 cages at a time and up to 5 mice per cage.

 Priced per day, for 0-8 cages

Expertise provided on study design, data interpretation, quality control, and analysis methods.

Mouse breeding, colony management, sample handling, restrain and care, and other laboratory techniques/services as defined by the animal protocol set forth by the project. These services will be performed by trained core staff using approved techniques.