The Animal Metabolism Phenotyping Core provides contemporary phenotyping techniques for metabolism and energy balance in mouse models of nutrition and disease.
The Animal Metabolism Phenotyping Core offers technical support and expertise for measuring traits related to metabolism in mouse models of obesity and nutritionally relevant disease. With locations in Chapel Hill and Kannapolis, the Core provides access to state-of-the-art methods, equipment, and populations to support high quality and high throughput phenotyping of energy balance components in mice.
Please submit service requests at least 2 weeks ahead of your preferred project start date to allow for scheduling.
Core staff will respond to your requests with a confirmation or alternative options within one business day.
The Animal Metabolism Phenotyping Core has adjusted the rate of EchoMRI services to $16 per mouse.
The rate increase is attributed to increased operational costs and will bring core services into alignment with guidance provided by The Office of Sponsored Research.
Our productivity and effectiveness as a Center is measured in part by the citation of our grant in your published work.
Please acknowledge National Institutes of Health grant DK056350 in all publications resulting from the use of our services.
Raz Shaikh, PhD
Director - Chapel Hill
phone: (919) 843-4348
email: shaikhsa@email.unc.edu
Stephen D. Hursting, PhD, MPH
Director - UNC Nutrition Research Institute
phone: (919) 966-7346
email: hursting@email.unc.edu
Hours | Locations |
8 AM - 5 PM
Monday - Friday |
Core Manager Office
Core Manager Office |
Name | Role | Phone | Location | |
---|---|---|---|---|
Raz Shaikh, PhD |
Director - Chapel Hill
|
(919) 843-4348
|
shaikhsa@email.unc.edu
|
Chapel Hill, NC
|
Stephen D. Hursting, PhD, MPH |
Director - Nutrition Research Institute
|
(919) 966-7346
|
hursting@email.unc.edu
|
Kannapolis, NC
|
Meagan D. Bridges, MS |
Manager - Chapel Hill
|
(919) 843-5145
|
bridgesmd@unc.edu
|
Chapel Hill, NC
|
Melissa VerHague, PhD |
Manager - Nutrition Reseach Institute
|
(704) 250-5049
|
melissa_verhague@unc.edu
|
Kannapolis, NC
|
Qing Shi, MS |
Manager - Seahorse Services
|
(919) 966-7162
|
qing_shi@med.unc.edu
|
Chapel Hill, NC
|
Service list |
► Chapel Hill Analysis Services (12) | |||
Name | Description | Price | |
---|---|---|---|
MRI (Analysis of Body Composition) - Chapel Hill |
MRI scanner technology is used is evaluate whole body composition (including fat, lean tissue and water) in live mice without anesthesia. This analysis also includes measurements for whole tissues and tissue biopsies. The Animal Metabolism Phenotyping Core has adjusted the rate of EchoMRI services to $15 per mouse. The rate increase is attributed to increased operational costs and will bring core services into alignment with guidance provided by The Office of Sponsored Research. Priced Per Mouse
|
Internal UNC-CH
$16.00
Sample
External $24.00 Sample |
|
Calorimetry (Analysis of Energy Expenditure/Food & Drink Consumption) - Chapel Hill |
![]() The calorimetry instrumentation (TSE systems) is used to evaluate and interpret energy expenditure in mice. The system measures O2 consumption & CO2 production, respiratory exchange rate, and energy expenditure in the home cage environment. The indirect calorimetry can also evaluate and interpret energy expenditure in 3-D (X, Y and Z dimension) via light beams for up to 10-days using intervals between 1 to 60 minutes in the home cage environment.
Priced Per Mouse/day
|
Internal UNC-CH
$33.00
Sample
External $52.00 Sample |
|
Voluntary Running Wheel (Analysis of Voluntary Exercise) |
Using the voluntary running wheel, daily summary measurements including total daily revolutions, time spent running (i.e., cumulative 1-minute intervals in which at least one revolution was recorded), average speed (total revolutions / time spent running) and maximum speed (highest number of revolutions in any one-minute interval within a 24 hour period) are recorded and analyzed in mice. Priced Per Mouse
|
Internal UNC-CH
$51.00
Sample
External $79.00 Sample |
|
Metabolic Cages for Collection of Urine and Feces - Chapel Hill |
This custom system combines 15 metabolic cages (Hatteras Instruments) and a cooling unit. The cooling unit keeps the urine samples at or below 45F during the collection. Different from traditional non-chilled metabolic cages, this system will prevent bacterial multiplication, improve sample quality and increase the sample shelf life. Useful for studies on the effects of drug therapies, urinary protein excretion, renal function studies, evaluation of standard or intervened metabolic function, and daily food and water intake. Suggested collection period, 6-24 hours. Priced Per Mouse
|
Internal UNC-CH
$12.00
Sample
External $19.00 Sample |
|
Treadmill (Analysis of Mouse Exercise Performance Measurement) |
The Exer-3/6 treadmill is a general purpose animal exerciser. This analysis includes 3 adaptations and one-maximal performance measurement. These tests help to examine the metabolic parameters in mice using speed, acceleration, and distance traveled as measures. The data is recorded and analyzed by the core using statistical Exer-3/6 software. Priced Per Mouse
|
Internal UNC-CH
$37.00
Sample
External $57.00 Sample |
|
Study Design and Data Interpretation - Chapel Hill |
Expertise provided on study design, data interpretation, quality control, and analysis methods. |
Internal UNC-CH
$96.00
/hr
External $149.00 /hr |
|
Animal Care, Handling, Sample Processing and Oversight |
Mouse breeding, colony management, sample handling, restrain and care, and other laboratory |
Internal UNC-CH
$30.00
/hr
External $47.00 /hr |
|
Seahorse XF Cell Mito Stress Test |
Performed with the Seahorse XFe96 analyzer, the XF Cell Mito Stress Test measures the key parameters of mitochondrial function. This service will be performed by trained core staff using approved techniques. Trained core staff will also provide training on the Seahorse XFe96 analyzer, including showing space/incubator, explaining how to save data and log hours, density/optimizations, plate layout, etc. |
Internal UNC-CH
$426.50
each
External $599.00 each |
|
Seahorse XF Glycolysis Stress Test |
Performed with the Seahorse XFe96, the XF Glycolysis Stress Test measures key parameters of glycolytic function. This service will be performed by trained core staff using approved techniques. Trained core staff will also provide training on the Seahorse XFe96 analyzer, including showing space/incubator, explaining how to save data and log hours, density/optimizations, plate layout, etc. |
Internal UNC-CH
$440.50
each
External $613.00 each |
|
Seahorse XF Glycolytic Rate Assay |
This service is performed with the Seahorse XFe96 analyzer by trained core staff using approved techniques. Trained core staff will also provide training on the Seahorse XFe96 analyzer, including showing space/incubator, explaining how to save data and log hours, density/optimizations, plate layout, etc. |
Internal UNC-CH
$374.00
each
External $514.50 each |
|
Seahorse XF Cell Energy Phenotype Test |
Performed with the Seahorse XFe96 analyzer, the XF Cell Energy Phenotype Test takes simultaneous measurements of oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) to provide a metabolic “snapshot” of samples. This service will be performed by trained core staff using approved techniques. Trained core staff will also provide training on the Seahorse XFe96 analyzer, including showing space/incubator, explaining how to save data and log hours, density/optimizations, plate layout, etc. |
Internal UNC-CH
$382.00
each
External $535.00 each |
|
Seahorse XF Real-Time ATP Rate Assay |
This service is performed with the Seahorse XFe96 analyzer by trained core staff using approved techniques. Trained core staff will also provide training on the Seahorse XFe96 analyzer, including showing space/incubator, explaining how to save data and log hours, density/optimizations, plate layout, etc. |
Internal UNC-CH
$367.00
each
External $507.50 each |
|
► Kannapolis Analysis Services (7) | |||
Name | Description | Price | |
MRI (Analysis of Body Composition) - Kannapolis |
MRI scanner technology used to evaluate whole body composition (including fat mass, lean mass, and free and total water masses) in live mice without anesthesia. Priced Per Mouse |
Internal UNC-CH
$14.00
Sample
External $23.00 Sample |
|
Calorimetry (Analysis of Energy Expenditure/Food & Drink Consumption) with cage activity- Kannapolis |
The calorimetry instrumentation (TSE systems) is used to evaluate and interpret energy expenditure in mice. The system measures O2 consumption & CO2 production, respiratory exchange rate, and energy expenditure in the home cage environment. The indirect calorimetry can also evaluate and interpret energy expenditure in 3-D (X, Y and Z dimension) via light beams for up to 10-days using intervals between 1 to 60 minutes in the home cage environment.
|
Internal UNC-CH
$18.00
Sample
External $32.00 Sample |
|
Calorimetry (Analysis of Energy Expenditure/Food & Drink Consumption) with voluntary running wheel - Kannapolis |
The calorimetry instrumentation (TSE systems) is used to evaluate and interpret energy expenditure in mice. The system measures O2 consumption & CO2 production, respiratory exchange rate, and energy expenditure in the home cage environment. Using a voluntary running wheel within the same cage, wheel activity is measured by daily summary measurements including total daily revolutions, time spent running (i.e., cumulative 1-minute intervals in which at least one revolution was recorded), average speed (total revolutions / time spent running) and maximum speed (highest number of revolutions in any one-minute interval within a 24 hour period) are recorded. Priced Per Mouse/day |
Internal UNC-CH
$18.00
each
External $32.00 each |
|
Metabolic Cages for Collection of Urine and Feces - Kannapolis |
This custom system combines 15 metabolic cages (Hatteras Instruments) and a cooling unit. The cooling unit keeps the urine samples at or below 45F during the collection. Different from traditional non-chilled metabolic cages, this system will prevent bacterial multiplication, improve sample quality and increase the sample shelf life. Useful for studies on the effects of drug therapies, urinary protein excretion, renal function studies, evaluation of standard or intervened metabolic function, and daily food and water intake. Suggested collection period, 6-24 hours.
|
Internal UNC-CH
$15.00
Sample
External $27.00 Sample |
|
Constant Climate Chamber - Kannapolis |
For behavioral, metabolic, or physiological experiments that require thermo-neutral conditions, the Constant Climate Chamber (Memmert HPP 750) provides full control over temperature, humidity and lighting conditions. The chambers have a temperature range (with light) from 0°C up to +40°C, and they can hold up to 16 cages at a time and up to 5 mice per cage. Priced per day, for 0-8 cages |
Internal UNC-CH
$11.00
Day
External $18.00 Day |
|
Study Design and Data Interpretation - Kannapolis |
Expertise provided on study design, data interpretation, quality control, and analysis methods. |
Internal UNC-CH
$175.00
/hr
External $273.00 /hr |
|
Animal Care, Handling, Sample Processing and Oversight - Kannapolis |
Mouse breeding, colony management, sample handling, restrain and care, and other laboratory techniques/services as defined by the animal protocol set forth by the project. These services will be performed by trained core staff using approved techniques. |
Internal UNC-CH
$36.00
/hr
External $56.00 /hr |